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- W2372071799 abstract "Objective To ascertain the role of NFκB and relationship among TGFβ1,caspase-3 and apoptosis in CsA-induced nephrotoxicity.Methods Sixty-four wistar male rats were randomly divided into 4 groups:Vehicle,PDTC,CsA and CsA + PDTC group.The animals were daily subcutaneously injected either with CsA(15 mg/kg)or vehicle/PDTC(100 mg/kg).Four weeks later,BUN,serum creatinine,NAG and urine routine were examined.The kidneys were processed for light microscopy,immunohistochemistry and TENUL.Results A rat model of CsA-induced nephrotoxicity was established.CsA group showed significant increase in BUN,SCr and urine NAG compared with the controls,whereas CsA + PDTC group did not.Apoptosis is observered by TUNEL and the expressions of NF-κB,TGF-β1,caspase-3 increased significantly in CsA group compared with conrtol group.Whereas,both the apoptosis and the expressions of these proteins significantly decreased in rats treated with PDTC.Conclusion Apoptosis is induced in the CsA-induced chronic nephrotoxicity.Inhibition of NF-κB activation blockaded apoptosis and ameliorated CsA-induced chronic nephrotoxicity.The results suggest that NF-κB plays important roles in the progression of chronic CsA nephrotoxicity." @default.
- W2372071799 created "2016-06-24" @default.
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- W2372071799 date "2007-01-01" @default.
- W2372071799 modified "2023-09-25" @default.
- W2372071799 title "Role of nuclear factor-κB in cyclosporin A-induced nephrotoxicity in rats" @default.
- W2372071799 hasPublicationYear "2007" @default.
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