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- W2372076277 abstract "Objective: To explore the possible role of glycoside of tripterygium wilfordii hook F (TWH) on rheumatoid arthritis (RA). Methods: Adjuvant induced arthritis rats (AA) was induced in Wistar rats. Arthritis rats were treated with TWH at the onset (14days) of arthritis. The area of articular cartilage was detected by image analysis. The expression of receptor activator of nuclear factor NF-κB(RANK)and receptor activator of nuclear factor NF-κB ligand (RANKL)in articular cartilage were detected by immunohistochemistry. Results: Compared with normal group, hyperplasia of synovial membrane was significant, the area of articular cartilage decreased (P 0.05), and expression of RANK and RANKL in articular cartilage increased in AA control group(P 0.05). By treated with TWH, hyperplasia of synovial membrane was depressed, the area of articular cartilage increased (P 0.05), and the expression of RANK and RANKL in articular cartilage decreased in TWH group compared with that of AA group(P 0.05). Conclusion: TWH may play a protective role in articular cartilage in RA by inhibiting hyperplasia of synovial membrane and expression of RANK and RANKL in articular cartilage." @default.
- W2372076277 created "2016-06-24" @default.
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- W2372076277 date "2007-01-01" @default.
- W2372076277 modified "2023-09-23" @default.
- W2372076277 title "The Protective Effect of Glycoside of Tripterygium Wilfordii Hook F on Articular Cartilage in Rat with Adjuvant Induced Arthritis" @default.
- W2372076277 hasPublicationYear "2007" @default.
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