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- W2372077041 abstract "Objective: To analyze the difference in the efficacy and safety of pantoprazole and H2 receptor antagonists(H2RA) in the prevention and treatment of stress ulcer bleeding in intracerebral hemorrhage patients.Methods: We searched PubMed,EMbase,the Cochrane Library(Central Register of Controlled Trials),CBM,CNKI and Wanfang database until the end of August 2012.Randomized controlled trials(RCTs) of pantoprazole for the prevention and treatment of stress ulcer bleeding in intracerebral hemorrhage patients were collected.Data were extracted and evaluated by two reviewers independently with a designed extraction form.The RevMan 5.0 software was used to carry out statistical analysis.Results: Sixteen RCTs involving 1 762 patients were included.The results of Meta-analyses showed that,as prophylaxis,pantoprazole significantly reduced the incidence of stress ulcer in intracerebral hemorrhage patients compared to H2RA group;as treatment,pantoprazole significantly increased efficiency of stress ulcer in intracerebral hemorrhage patients compared to H2RA group;as prophylaxis,mortality was significantly lower in pantoprazole group than in H2RA group.Conclusion: The currently available evidence shows that pantoprazole as a preventive medication can reduce the incidence of stress ulcer and mortality in intracerebral hemorrhage patients;pantoprazole as a treatment medication can improve efficiency of stress ulcer bleeding compared to H2RA group." @default.
- W2372077041 created "2016-06-24" @default.
- W2372077041 creator A5036421260 @default.
- W2372077041 date "2013-01-01" @default.
- W2372077041 modified "2023-09-24" @default.
- W2372077041 title "Efficacy comparison of pantoprazole and H_2 receptor antagonists in preventing and treating stress ulcer bleeding in intracerebral hemorrhage patients: a Meta-analysis" @default.
- W2372077041 hasPublicationYear "2013" @default.
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