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- W2372078148 abstract "Objective To investigate the effects of HIV and combination antiretroviral therapy (cART) on mitochondrial DNA content in peripheral blood mononuclear cells (PBMCs) and the relationship between mitochondrial DNA content and lipodystrophy (LD).Methods The mitochondrial DNA level in PBMCs from 20 HIV infected patients,40 ART experienced patients were determined using real-time PCR,with 20 healthy individuals serving as the normal controls.Results The mitochondrial DNA level in the PBMCs from patients with HIV was slightly lower than that in normal controls.The mtDNA content in PBMCs from patients with LD was significantly lower than that from patients without LD.Conclusions HIV infection and/or cART might lead to mitochondrial DNA in PBMC depletion.There is correlation between the amount of mitochondrial DNA in PBMC to LD but still need further evaluation." @default.
- W2372078148 created "2016-06-24" @default.
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- W2372078148 date "2010-01-01" @default.
- W2372078148 modified "2023-09-23" @default.
- W2372078148 title "The effect of HIV infection and combination antiretroviral therapy on the mitochondrial DNA in PBMC from HIV/AIDS patients" @default.
- W2372078148 hasPublicationYear "2010" @default.
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