Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372091929> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2372091929 abstract "Objective To discuss the therapeutical effect of different concentrations of silver nanoparticles against influenza in mice.Methods Forty-eight Kun Ming mice,which were healthy and weigh 18-22 g,were randomly divided into normal control group,model group,positive control group,high dose group(the concentration of silver nanoparticles is 400 μg/mL),middle dose group(100 μg/mL) and low dose group(25 μg/mL).Mice were infected with the influenza virus A/PR/8/34 H1N1(PR8 H1N1) and intranasal administration of silver nanoparticles at different concentrations after 4 hours,and treated continuously 3 days.Record the general physical condition,the condition of life and death count of each group every day for 14 days.To study the curative effect of silver nanoparticles at different concentrations against influenza in mice,the indexes that mortality rate,survival days,lung index,lung virus titer,lung histopathological examination and lung bacterial infections of each group were used.Results Compared with model group,the mortality of high,middle and low dose group reduced obviously,and monse survival days in these gvoup were significantly longer(P0.01).The lung index of high,middle and low dose group reduced and the high and middle dose group reduced significantly(P0.01).The lung virus titer of model group was 1∶512,and some mice were as high as 1∶1024;the with hist in the high,middle and low dose group was 1∶2.In model group,the morphological structure of lung tissue was disappeared,the alveolar walls were thickened,a large number of red blood cells wlhe found,and the edema fluid was found in alveolar cavity.In high dose group,the pathological changes of lung tissue were obviously alleviated,and it is no edema fluid in alveolar cavity.There were large numbers of bacteria in model group,the bacterial content in high,middle and low dose group reduced significantly(P 0.01).Conclusion Two silver nanoparticles would hmte therapeutic effect on influenza in mice,and the curative effect was dose dependent." @default.
- W2372091929 created "2016-06-24" @default.
- W2372091929 creator A5059196718 @default.
- W2372091929 date "2013-01-01" @default.
- W2372091929 modified "2023-09-26" @default.
- W2372091929 title "Therapeutic effect of silver nanoparticles against influenza in mice" @default.
- W2372091929 hasPublicationYear "2013" @default.
- W2372091929 type Work @default.
- W2372091929 sameAs 2372091929 @default.
- W2372091929 citedByCount "0" @default.
- W2372091929 crossrefType "journal-article" @default.
- W2372091929 hasAuthorship W2372091929A5059196718 @default.
- W2372091929 hasConcept C102652120 @default.
- W2372091929 hasConcept C126322002 @default.
- W2372091929 hasConcept C203014093 @default.
- W2372091929 hasConcept C2522874641 @default.
- W2372091929 hasConcept C2777546802 @default.
- W2372091929 hasConcept C2777714996 @default.
- W2372091929 hasConcept C32611913 @default.
- W2372091929 hasConcept C71924100 @default.
- W2372091929 hasConcept C85663871 @default.
- W2372091929 hasConcept C90924648 @default.
- W2372091929 hasConceptScore W2372091929C102652120 @default.
- W2372091929 hasConceptScore W2372091929C126322002 @default.
- W2372091929 hasConceptScore W2372091929C203014093 @default.
- W2372091929 hasConceptScore W2372091929C2522874641 @default.
- W2372091929 hasConceptScore W2372091929C2777546802 @default.
- W2372091929 hasConceptScore W2372091929C2777714996 @default.
- W2372091929 hasConceptScore W2372091929C32611913 @default.
- W2372091929 hasConceptScore W2372091929C71924100 @default.
- W2372091929 hasConceptScore W2372091929C85663871 @default.
- W2372091929 hasConceptScore W2372091929C90924648 @default.
- W2372091929 hasLocation W23720919291 @default.
- W2372091929 hasOpenAccess W2372091929 @default.
- W2372091929 hasPrimaryLocation W23720919291 @default.
- W2372091929 hasRelatedWork W2079122811 @default.
- W2372091929 hasRelatedWork W2333268705 @default.
- W2372091929 hasRelatedWork W2348335978 @default.
- W2372091929 hasRelatedWork W2354189070 @default.
- W2372091929 hasRelatedWork W2357444572 @default.
- W2372091929 hasRelatedWork W2366613700 @default.
- W2372091929 hasRelatedWork W2368024799 @default.
- W2372091929 hasRelatedWork W2371984372 @default.
- W2372091929 hasRelatedWork W2374010063 @default.
- W2372091929 hasRelatedWork W2382434127 @default.
- W2372091929 hasRelatedWork W2387930885 @default.
- W2372091929 hasRelatedWork W2388621012 @default.
- W2372091929 hasRelatedWork W2392213084 @default.
- W2372091929 hasRelatedWork W2392740055 @default.
- W2372091929 hasRelatedWork W2411405729 @default.
- W2372091929 hasRelatedWork W2424687881 @default.
- W2372091929 hasRelatedWork W2437128378 @default.
- W2372091929 hasRelatedWork W2460822514 @default.
- W2372091929 hasRelatedWork W2767478004 @default.
- W2372091929 hasRelatedWork W3000526557 @default.
- W2372091929 isParatext "false" @default.
- W2372091929 isRetracted "false" @default.
- W2372091929 magId "2372091929" @default.
- W2372091929 workType "article" @default.