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- W2372095345 abstract "AIM: To investigate the effects of hyperbaric oxygen (HBO) treatment on the expression of protein Bcl 2 and delayed neuronal damage in the rat hippocampus after acute carbon monoxide poisoning. METHODS: 45 Sprague Dawley male rats were randomly divided into three groups: control group, CO exposed group and HBO treated group (0.25 MPa HBO). General hematoxylin eosin (HE) stain, immunohistochemistry stain and TUNEL stain were used to observe the neurological damage and the changes of Bcl 2 expression in the rat hippocampus at 1, 3, 5 and 7 days after CO exposure. RESULTS: Delayed neuronal damage appeared in the brain of CO exposed group. In the group of HBO treated, the number of neuronal apoptosis significantly decreased and the expression of protein Bcl 2 increased compared with those in the CO exposed group. 3 and 5 days after CO exposure, the expression of protein Bcl 2 significantly increased ( P 0.05). CONCLUSION: HBO treatment can promote the expression of protein Bcl 2 in the rat hippocampus following acute carbon monoxide poisoning and protect neuronal cells by inhibiting neuronal apoptosis." @default.
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- W2372095345 date "2003-01-01" @default.
- W2372095345 modified "2023-09-24" @default.
- W2372095345 title "Effects of hyperbaric oxygen on expression of Bcl-2 and delayed neuronal damage following acute carbon monoxide poisoning in the brain of rats" @default.
- W2372095345 hasPublicationYear "2003" @default.
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