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- W2372147676 abstract "Objective To investigate the incidence and analyze the risk factors of parenteral nutrition-associated cholestasis(PNAC)in very low birth weight infants(VLBWI).Methods Retrospective analysis on the data collected from Jan.2006 to Dec.2008 was performed.VLBWI received parenteral nutrition(PN)for more than 14 days in Nanjing Children's Hospital were investigated in this study.Sixty-four neonates were divided into PNAC group and non-PNAC group.The associated factors were analyzed.Results The incidence of PNAC in VLBWI was 15.63%(10/64 cases).The gestational age of PNAC group was(31.54±2.67)weeks,lower than that of non-PNAC group[(33.30±2.01)weeks](P=0.003).The weight gain of PNAC group was(12.14±8.44)g·d-1,lower than that of non-PNAC group[(17.66±4.36)g·d-1](P=0.003).In PNAC group,duration of hospitalization was(50.30±32.15)d,duration of PN was(35.00±12.12)d,duration of total PN was(9.44±8.52)d,amio acid intake of PN was(57.62±25.25)g·kg-1,fat intake of PN was(55.23±30.60)g·kg-1,which were all significantly higher than those of non-PNAC group.While the incidence of infection,asphyxia and intracranial hemorrhage had no significant difference,the same as sex,birth weight and age.Of these risk factors,duration of PN(OR=0.87,95%CI 0.79-0.96,P=0.005)and with congenital heart disease(OR=39.44,95%CI 2.18-714.24,P=0.013)were most significant after multivariate Logistic regression analysis.Conclusions Young gestational age,long duration of total enteral feeding,long duration of PN are significant risk factors for PNAC in this study.Neonates with congenital heart disease are prone to PNAC.Early enteral feeding and shortened duration of PN are the important measures to lower PNCA." @default.
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- W2372147676 date "2011-01-01" @default.
- W2372147676 modified "2023-09-23" @default.
- W2372147676 title "Clinical Analysis of Risk Factors of Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants" @default.
- W2372147676 hasPublicationYear "2011" @default.
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