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- W2372150244 abstract "Objective To study the effect of WR-2721 on preventing DNA damage and hematopoietic lesion in mice treated with VP-16.Methods The Kunming strain mice were randomly divided into nine groups(n=10 in each group) and received different doses of VP-16 alone(A1,A2,A3),VP-16 combined with WR-2721(B1,B2,B3),equal volume of saline(C) and WR-2721 alone(D).The ratios of cells with DNA damage and DNA migration were resolved by single cell gel electrophoresis.The ratios of cells with micronuclei in PCE were compared in different groups.The protective effect of WR-2721 was also tested in terms of survival rates,PWBC,CFU-GM.Results After combined with WR-2721,both the ratios for micronuclei in PCE,lymphocytes with DNA damage,the DNA migration and the survival rate of 30 d,mean survival days,PWBC and CFU-GM were ameliorated significantly.Conclusion WR-2721 could lessen effectively DNA damage and hematopoietic lesion of the mice induced by VP-16." @default.
- W2372150244 created "2016-06-24" @default.
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- W2372150244 date "2010-01-01" @default.
- W2372150244 modified "2023-09-25" @default.
- W2372150244 title "Effect of WR-2721 on preventing DNA damage and hematopoietic lesion of mice induced by VP-16" @default.
- W2372150244 hasPublicationYear "2010" @default.
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