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- W2372150882 abstract "Objective To investigate the apoptosis mechanism induced by micromolecule compound S1 in human ovarian cancer cells SKOV3.Methods Inverted phase contrast microscope was used to observe S1 induced cell morphology changes in SKOV3 cells.Mito- chondrial membrane potential was detected by JC-1 staining and Flow cytometry analysis.Western blot was used to analyze the expression of the protein of Cyto c,Bcl-2 and Bax.Results S1 significantly induced the SKOV3 cells death.The treatment of S1 decreased mitochondrial membrane potential,resulted mitochondrial injury.S1 treatment increased the ratio of Bax / Bcl-2,and enhanced the expression of cytosolic cytochrome C.Conclusions S1 could efficiently induce intracellular apoptosis through mitochondrial pathway in human ovarian cancer cells SKOV3." @default.
- W2372150882 created "2016-06-24" @default.
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- W2372150882 date "2014-01-01" @default.
- W2372150882 modified "2023-09-23" @default.
- W2372150882 title "S1 induce human ovarian cancer cell apoptosis through mitochondrial pathway" @default.
- W2372150882 hasPublicationYear "2014" @default.
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