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- W2372156155 abstract "Objective To investigate the association between the JAK2V617F gene and thrombosis in essential thrombocythemia patients. Method The studies were identified by searching Chinese and English databases including Pubmed, Embase,Chinese Biomedical Literature Database and Wanfang Data. The Odds ratios( OR) and 95% confidence intervals( CI) were calculated using the rate of thrombosis in essential thrombocythemia patients with positive and negative JAK2V617F. The Meta analysis was conducted and bias in studies was evaluated by RevMan 5. 2 and Stata 11. 0 software. Result Twenty-three studies involving patients with essential thrombocythemia were included,and a total of 1710 JAK2V617F positive cases and 1263 negative cases were analyzed. JAK2V617F was associated with a significant increased risk of thrombosis( OR = 3. 13,95% CI: 2. 26- 4. 34),while subgroup analysis showed no difference between Asia group( OR=4. 98,95% CI: 2. 92- 8. 52) and non-Asia( OR=2. 32,95% CI: 1. 62- 3. 33) by using random effects model.Conclusion JAK2V617F increases the risk of thrombosis in essential thrombocythemia patients significantly." @default.
- W2372156155 created "2016-06-24" @default.
- W2372156155 creator A5014569032 @default.
- W2372156155 date "2014-01-01" @default.
- W2372156155 modified "2023-09-23" @default.
- W2372156155 title "Association between JAK2V617F gene and thrombosis in essential thrombocythemia patients: a meta-analysis" @default.
- W2372156155 hasPublicationYear "2014" @default.
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