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- W2372169190 abstract "Objective To evaluate the changes of tumor cell apoptosis prior to and after different doses of radiotherapy in patients with nasopharyngeal carcinoma (NPC) and to determine whether the frequency of apoptosis was correlated with prognosis. Methods Twenty five patients histologically proven to be nasopharyngeal squamous cell carcinoma were eligible to enter into this study. Patients were divided into 5 groups, 5 patients per group. Pretherapy biopsy and second biopsy from the nasopharyngeal tumor 3～6 hours after 1～5 fractions irradiation respectively (1.9?Gy per fraction a day) were taken. Apoptotic cells were identified and quantified by the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method. Results The mean of apoptotic index prior to and after radiotherapy were 0.44 (range: 0.10～1.15) and 0.51 (range:0.05～ 1.40 ) respectively (P0.05). But the AI after 9.5?Gy in 5 fractions was significantly higher than that of pretherapy (0.98 versus 0.44, P=0.009). The disease free survival curve for patients with a low AI (0.35) was not significantly different from that for those with a high AI (≥0.35), P0.05. Univariate and multivariate analysis indicated that the AI of pretherapy biopsy showed no prognostic value. Conclusions The tumor cell AI after doses of 9.5?Gy in 5 fractions was higher than that of pretherapy for 25 patients with NPC in this study. Analysis with Cox regression models did not show the apoptotic index prior to treatment to be an independent prognostic factor." @default.
- W2372169190 created "2016-06-24" @default.
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- W2372169190 modified "2023-09-27" @default.
- W2372169190 title "Prognostic significance of apoptosis prior to and after different doses of radiotherapy in nasopharyngeal carcinoma: preliminary report" @default.
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