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- W2372180888 abstract "Effects of exogenous GM3 or GD3 on cytosolic free calcium([Ca2+]1) in the SMMC-7721 cultured human hepatoma cells were monitored by the fluorescence probe fura-2 and the results Proved that both GM3 and CD3 could stimulate a rapid tranaient increase of [Ca2+]1 with quite differrent levels.[Ca2+]1 could be elavated to the higheds level by a dose of 10 nmol/ml GM3 or 1 nmol/ml GD3 with the increasing rate up to 215-250% and 42% respectively as compared with the control. Further studies on the mode of action of GM3 and GD3 were carried out in differently treated systems,such as by using verapamil,the inhibitor of caleium channel in plasma membrane and calcium-releasing system of endoplasmic recticu recticum(ER); or removing Na+ from the culture media to inhibit Na+-Ca2+ exchanger;or remoting Ca2+ from the culture media to block the enter of extracellular Ca2+.The results demonstrated that the mechanism of elevating [Ca2+]1 by GM3was through activating calcium channel,releasing Ca2+ from ER rapidly and stimulatingthe Ca2+-ATPase on the plasma membranes; that by GD3 was through inhibiting Na+-Ca2+ exchanger mainly." @default.
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- W2372180888 date "1994-01-01" @default.
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- W2372180888 title "The Mode of Action of Exogenous Gangliosides on Cytosolic Calcium of Cultured Human Hepatoma Cells" @default.
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