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- W2372181799 abstract "Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase, highly conservedand has been identified inevery eukaryoteinvestigated to date. It is encoded by two isoforms in mammals,termed GSK-3a and GSK-3b. GSK-3plays an importantrole in at least three signal transductorysystems, namely, the Wnt/wingless, Hedgehog and PI3-kinasepathways, which influence proliferation and cell survival, respectively, highlighted by the wide array of substratescontrolled by thisenzyme that includes cytoplasmic proteins and nucleartranscription factors. Several diseases such as innon-insulin dependent diabetes metillus (NIDDM), Alzheimers disease, neurological disorders, and cancer have beenrelated to GSK-3, as a potentialtherapeutic target.Several new GSK-3 inhibitors, such as the aloisines, the paullones andthe maleimides, have been developed. Although they are just starting to be characterized in cell culture and animal modelexperiments, these new inhibitors hold promise as therapeutic agents." @default.
- W2372181799 created "2016-06-24" @default.
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- W2372181799 date "2005-01-01" @default.
- W2372181799 modified "2023-09-23" @default.
- W2372181799 title "Multi-function kinase: glycogen synthase kinase-3" @default.
- W2372181799 hasPublicationYear "2005" @default.
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