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- W2372190305 abstract "Objective Claudin-7 is up-regulated in colorectal cancer tissue and plays an important role in tumorigenesis and metastasis.This study was to investigate the effects of CpG Methyltransferase(M.SssI) on the apoptosis and proliferation of human colorectal cancer cell line HT-29 and the expression of claudin-7 in vitro.Methods HT-29 cells were divided into three groups to be treated with M.SssI(50U/ml),PBS(2 μl) and 5-Azacytidine(10 μmol/L) respectively.After 24 hours,the apoptosis of the cells was measured by flow cytometry,their proliferation determined by MTT assay,and the localization and expression of claudin-7 detected by cell immunofluorescence.Results The early apoptosis rate was remarkably higher in the M.SssI(P0.05) but lower in the 5-Azacytidine(P0.05) than in the PBS group.M.SssI inhibited the proliferation of the HT-29 cells by 32.1%(P0.05) while 5-Azacytidine promoted it(P0.05).The expression level of claudin-7 was significantly lower in the M.SssI(P0.05) but markedly higher in the 5-Azacytidine(P0.05) than in the PBS group.Conclusion M.SssI promotes the apoptosis and inhibits the proliferation of HT-29 cells,which can be attributed to the high methylation of the gene promoter and decreased expression of claudin-7 induced by CpG Methyltransferase." @default.
- W2372190305 created "2016-06-24" @default.
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- W2372190305 date "2012-01-01" @default.
- W2372190305 modified "2023-09-26" @default.
- W2372190305 title "CpG methyltransferase induces the apoptosis of human colorectal cancer cell line HT-29" @default.
- W2372190305 hasPublicationYear "2012" @default.
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