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- W2372192613 abstract "Objective To investigate the effect of miR-181a on the sensitivity of A549/DDP cells to cisplatin and its mechanism.Methods A549/DDP cells were transfected with miR-181a mimic.The cell growth was detected by MTT method.The expression of microRNA-181a was measured by fluorescence quantitative polymerase chain reaction.Bcl-2 protein level was determined by Western blotting.The apoptosis of cells was measured by Annexin V/PI methods.Results miR-181a significantly enhanced the sensitivity of A549/DDP cells to cisplatin and the apoptosis induced by cisplatin.After transfected with microRNA-181a mimic,Bcl-2 protein level decreased in A549/DDP cells.Conclusions MicroRNA-181a can enhance the sensitivity of A549/DDP cells to cisplatin,which may be associated with down-regulation of Bcl-2 expression." @default.
- W2372192613 created "2016-06-24" @default.
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- W2372192613 date "2012-01-01" @default.
- W2372192613 modified "2023-09-23" @default.
- W2372192613 title "MicroRNA-181a enhances the sensitivity of A549/DDP cells to cisplatin via inhibiting Bcl-2 expression" @default.
- W2372192613 hasPublicationYear "2012" @default.
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