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- W2372194877 abstract "Objective To explore the experimental therapeutic effect of interleukin-18 binding protein(IL-18BP) through binding endogenous IL-18 inhibit downstream inflammation factors releasing on adriamycin(ADR)-induced nephropathy in mice. Methods Kunming mice were induced to nephropathy model by single injection of ADR(7.5 mg·kg~-1) through tail vena.Then the mice were treated with murine-IL-18BP with 0.5 mg·kg~-1 as the IL-18BP-treated group,and the mice were treated with phosphate buffered saline(PBS) of the same volume as the ADR-minimal change nephropathy(MCN) group on day 5,7,12 and 21.Urine protein was measured biweekly and objective sign of mice were recorded.All mice were sacrificed through getting blood from the heart on the 42~th day after the first injection of ADR.The renal histological changes were observed under electron microscope when mice were sacrificed. Results 1.All ADR-mice develo-ped nephropathy characterized by proteinuria,hypoalbuminemia,hypercholasterolnemia,and progressive renal injury.2.In IL-18BP-treated group,the urine protein rates decreased significantly compared with those in ADR-MCN group,but increased significantly compared with those in normal control group(P_a0.01).3.In ADR-MCN group,the levels of tiglyceride and cholesterol were higher,and total protein and albumin were lower than those in IL-18BP-treated group and normal control group in serum(P_a0.01).There were no significant diffe-rence among three groups of the levels of blood urea nitrogen and serum creatinine(P_a0.05).4.In IL-18BP-treated group,the levels of IL-18,interferon-γ(IFN-γ) and tumor necrosis factor-α(TNF-α) in serum decreased significantly compared with those in ADR-MCN group(P_a0.05),the level of IL-4 rose again(P0.01).5.In ADR-MCN group,glomerulus epithelical cells were hologamy or vanished,yet there were only meromixis in IL-18BP-treated group by transmission electron microscope. Conclusions IL-18 and its downsteam cytokines(IFN-γ,TNF-α) may play important roles in the formation of the mice with ADR-induced nephropathy.It may be a key pathogenic factor affect the growth of the disease and outcome.IL-18BP has obvious therapeutic effect on ADR nephrosis mice through specific binding IL-18,therefore regulates immunologic balance,and strengthens renal function." @default.
- W2372194877 created "2016-06-24" @default.
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- W2372194877 date "2011-01-01" @default.
- W2372194877 modified "2023-09-22" @default.
- W2372194877 title "Effect of Interleukin-18 Binding Protein on Adriamycin Nephropathy Model Mice" @default.
- W2372194877 hasPublicationYear "2011" @default.
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