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- W2372203018 abstract "Objective: To investigate the antitumor effect of Zhenhuang capsule(ZHC) on human esophageal carcinoma and research its mechanisms.Methods: ①Apoptosis induced by ZHC in human esophageal carcinoma cell line EC109 was investigated by light microscopy,transmission electron microscopy combined with flow cytometry analysis technique.② A perfusing test with ZHC was conducted on nude mice 8 days after the human esophageal carcinoma transplantation.The animals were divided into 5 groups: high ZHC dose group(2.4g/kg,BW),medium ZHC dose group(1.2g/kg),low ZHC dose group(0.6g/kg),positive control group of Pingyangmycin(15mg/kg) and saline control group.ZHC was perfused into stomach,once daily,with 36 times consitituting one course.Pingyangmycin was injected intraperitaneously,once every three days,12 times consitituting one course.The test was repeated 2 times.Results: ①After exposure to ZHC,EC109 cells manifested typical apoptotic features.②The tumor-inhibiting rates of the high,medium and low dose ZHC groups ranged from 66.36% to 76.85%(p0.01),54.21% to 55.56%(p0.01) and 38.32% to 39.81%(p0.01),respectively.The tumor-inhibiting rate of the Pingyangmycin group ranged from 51.40% to 56.48%(p0.01).Conclusion: ①ZHC induces apoptosis of esophageal carcinoma cells and ZHC induced apoptotsis possibly the primary mechanism of ZHC for treatment of esophageal carcinoma.② ZHC has significant antitumor effect on human esophageal carcinoma transplanted into nude mice receiving tolerance doses.The effect increase with elevation of dose." @default.
- W2372203018 created "2016-06-24" @default.
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- W2372203018 date "2006-01-01" @default.
- W2372203018 modified "2023-09-26" @default.
- W2372203018 title "Antitumor Effect of Zhenhuang Capsule on Human Esophageal Carcinoma and its Mechanisms" @default.
- W2372203018 hasPublicationYear "2006" @default.
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