Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372205508> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2372205508 abstract "To test the effect on human pregnane X receptor(hPXR)-mediated transcription regulation of CYP 3A 4 by selected anti-hyperglycemic agents,transient cotransfection reporter gene assays in HepG2 cells were performed with the hPXR expression plasmid and the reporter gene plasmid which contains XRE in the promoter of CYP 3A 4 linked to luciferase.In the dose-effect study,wu wei zi(Schisandra),niu pang zi(Burdock),ju luo(Juluo) and Mitiglinide induced the CYP 3A 4 transcription via PXR in an evident dose-dependent manner,but other anti-hyperglycemic agents in this experiment did not.In the time-effect study,wu wei zi,niu pang zi,ju luo and Mitiglinide induced CYP 3A 4 transcription between 12h and 36h,the strongest induction appeared in 36h.So three herb extracts,wu wei zi,niu pang zi,ju luo and Mitiglinide stimulate the PXR-mediated transcription of CYP 3A 4.Other anti-hyperglycemic agents in this experiment have no effect on the CYP 3A 4 transcription via PXR." @default.
- W2372205508 created "2016-06-24" @default.
- W2372205508 creator A5000232806 @default.
- W2372205508 date "2007-01-01" @default.
- W2372205508 modified "2023-09-28" @default.
- W2372205508 title "Transcriptional Reyulation of some Antityperglycemic Agents on Cytochrome P450 3A4" @default.
- W2372205508 hasPublicationYear "2007" @default.
- W2372205508 type Work @default.
- W2372205508 sameAs 2372205508 @default.
- W2372205508 citedByCount "0" @default.
- W2372205508 crossrefType "journal-article" @default.
- W2372205508 hasAuthorship W2372205508A5000232806 @default.
- W2372205508 hasConcept C104317684 @default.
- W2372205508 hasConcept C109650736 @default.
- W2372205508 hasConcept C111335760 @default.
- W2372205508 hasConcept C132040763 @default.
- W2372205508 hasConcept C138885662 @default.
- W2372205508 hasConcept C150194340 @default.
- W2372205508 hasConcept C161733203 @default.
- W2372205508 hasConcept C179926584 @default.
- W2372205508 hasConcept C181199279 @default.
- W2372205508 hasConcept C185592680 @default.
- W2372205508 hasConcept C41895202 @default.
- W2372205508 hasConcept C526171541 @default.
- W2372205508 hasConcept C54009773 @default.
- W2372205508 hasConcept C55493867 @default.
- W2372205508 hasConcept C63932345 @default.
- W2372205508 hasConcept C86339819 @default.
- W2372205508 hasConcept C86803240 @default.
- W2372205508 hasConcept C98274493 @default.
- W2372205508 hasConceptScore W2372205508C104317684 @default.
- W2372205508 hasConceptScore W2372205508C109650736 @default.
- W2372205508 hasConceptScore W2372205508C111335760 @default.
- W2372205508 hasConceptScore W2372205508C132040763 @default.
- W2372205508 hasConceptScore W2372205508C138885662 @default.
- W2372205508 hasConceptScore W2372205508C150194340 @default.
- W2372205508 hasConceptScore W2372205508C161733203 @default.
- W2372205508 hasConceptScore W2372205508C179926584 @default.
- W2372205508 hasConceptScore W2372205508C181199279 @default.
- W2372205508 hasConceptScore W2372205508C185592680 @default.
- W2372205508 hasConceptScore W2372205508C41895202 @default.
- W2372205508 hasConceptScore W2372205508C526171541 @default.
- W2372205508 hasConceptScore W2372205508C54009773 @default.
- W2372205508 hasConceptScore W2372205508C55493867 @default.
- W2372205508 hasConceptScore W2372205508C63932345 @default.
- W2372205508 hasConceptScore W2372205508C86339819 @default.
- W2372205508 hasConceptScore W2372205508C86803240 @default.
- W2372205508 hasConceptScore W2372205508C98274493 @default.
- W2372205508 hasLocation W23722055081 @default.
- W2372205508 hasOpenAccess W2372205508 @default.
- W2372205508 hasPrimaryLocation W23722055081 @default.
- W2372205508 hasRelatedWork W1913420541 @default.
- W2372205508 hasRelatedWork W1974721104 @default.
- W2372205508 hasRelatedWork W1975594696 @default.
- W2372205508 hasRelatedWork W1985236712 @default.
- W2372205508 hasRelatedWork W1990805806 @default.
- W2372205508 hasRelatedWork W1993738314 @default.
- W2372205508 hasRelatedWork W1999334420 @default.
- W2372205508 hasRelatedWork W2011968727 @default.
- W2372205508 hasRelatedWork W2074387695 @default.
- W2372205508 hasRelatedWork W2133380940 @default.
- W2372205508 hasRelatedWork W2145934753 @default.
- W2372205508 hasRelatedWork W2151552217 @default.
- W2372205508 hasRelatedWork W2379339487 @default.
- W2372205508 hasRelatedWork W2463059895 @default.
- W2372205508 hasRelatedWork W2800419358 @default.
- W2372205508 hasRelatedWork W2888575047 @default.
- W2372205508 hasRelatedWork W2945899524 @default.
- W2372205508 hasRelatedWork W2970497317 @default.
- W2372205508 hasRelatedWork W3018951541 @default.
- W2372205508 hasRelatedWork W3130432488 @default.
- W2372205508 isParatext "false" @default.
- W2372205508 isRetracted "false" @default.
- W2372205508 magId "2372205508" @default.
- W2372205508 workType "article" @default.