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- W2372215865 abstract "Objective To demonstrate that 188 Re-anti-carcinoembryonic antigen (CEA)-monoclonal antibody (McAb) ( 188 Re-C50) has an anti-tumor effect by inducing apoptosis on colon cancer cells. Methods The model mice of colon cancer (C26) were sacrificed at 6 h after intratumoral injection of 18.5 MBq 188 Re-C50 (treatment group, n =8) or 0.16 mg C50 (control group,n= 8). The single cell suspension of fresh tumor tissue was prepared and the flow cytomytry (FCM) was used to analyze the ploidy and proportion of S-phase cells of the tumor cells in the suspension. Additionally,the tumor tissue samples were examined by transmission electron microscope and terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end-labeling (TUNEL). Results Apoptotic sub-G 1 peak was observed in FCM histogram 6 h after radioimmunotherapy (RIT) in C26 colon cancer cells and the apoptotic index was (16.64±0.12)% vs 0% of control group. The S-phase ratio of RIT group was (10.41±1.31)% and that of control group was (33.14±2.01)%. G 0-G 1 phase ratio of tumor cells in RIT group was (68.60±4.82)% and (35.12±2.63)% in control group. Tumor cells were apparently detained in stage G 1 in RIT group. Apoptosis was also observed in TUNEL assay in RIT group and the apoptosis index was (26.4±0.97)%,but it was not observed in the control group. Typical morphologic transformation such as the apoptotic body was observed by transmission electron microscopy. Conclusion 188 Re-C50 can induce cancer cell apoptosis and probably it's the important mechanism of anti-tumor effect of RIT" @default.
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- W2372215865 date "2004-04-25" @default.
- W2372215865 modified "2023-09-27" @default.
- W2372215865 title "The apoptotic effect of 188 Re-anti-CEA-McAb radioimmunotherapy on colon cancer" @default.
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