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- W2372226286 abstract "Objective: To investigate the influence of Dachengqi decoction on the activation of protease-activated receptor 1 in heart and lung of rabbits with post-cardiac arrest syndrome( PCAS). Methods: Rabbits were used to establish PCAS model by using asphyxia-induced cardiac arrest,and another five healthy rabbits were selected as normal control group. Rabbits which resuscitate successfully with return of spontaneous circulation( ROSC) were randomly assigned into two groups: PCAS group and Dachengqi decoction group. Dachengqi decoction group was given Dachengqi 15 g / kg per day by intragastric administration 15 minutes after ROSC. After 48 hours,animals' blood were drawn in each group for detecting organ function,then animals were sacrificed,and tissue samples of heart and lung were taken and the level of PAR-1 protein was analyzed by Western blot method. Results: The level of PAR-1 protein in heart and lung in PCAS group were decreased( all P 0. 01). The level of PAR-1 protein in Dachengqi decoction group were higher than that in PCAS group( P 0. 05). Conclusions: There was excessive activation of protease-activated receptor 1 in PCAS. Dachengqi decoction inhibited the activation of protease-activated receptor 1 in rabbits with PCAS." @default.
- W2372226286 created "2016-06-24" @default.
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- W2372226286 date "2014-01-01" @default.
- W2372226286 modified "2023-09-27" @default.
- W2372226286 title "Dachengqi decoction inhibits the activation of protease-activated receptor 1 in heart and lung of rabbits with postcardiac arrest syndrome" @default.
- W2372226286 hasPublicationYear "2014" @default.
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