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- W2372241904 abstract "To study the combination effects of oncolytic adenovirus SG500-IL-24(double-regulated by hTERT promoter and HRE)and chemotherapy against human colorectal cancer cell lines in vitro.Methods:(1) To test the growth inhibition effects of combinational therapy on cancer cell lines HCT-116,SW620 and human normal cell line L02 by MTT assay;(2) after Hoechst 33342 dying,the apoptosis of HCT-116 induced by the viro-chemotherapy is observed under fluorescent microscope;(3) the changes in apoptosis signaling pathway are detected by Western blot.The kill effects of either SG500-IL24 or SG500 are significantly improved when in combination of low does cisplatin(p0.05),while the toxicity against normal cell line L02 is not apparent.Our primary study demonstrates that the combinational therapy achieves better therapeutic results through the up-regulation of caspase-dependent apoptotic signaling." @default.
- W2372241904 created "2016-06-24" @default.
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- W2372241904 date "2008-01-01" @default.
- W2372241904 modified "2023-09-25" @default.
- W2372241904 title "Cisplatin Can Increase the Anti-Colorectal Tumor Cell Lines Efficacy of Dual Regulated Oncolytic Adenovirus Mediate IL-24" @default.
- W2372241904 hasPublicationYear "2008" @default.
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