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- W2372242023 abstract "Objective: To investigate the effects of Zhi Tang Shu (ZTS) on the T lymphocyte subgroups in blood and the immuno-organs coefficients of diabetic rats. Methods: The diabetic rats model was established by abdominal injection of small dosage (30mg/kg) of streptozotocin for three times, every three days a time. Metformin hydrochloride tablets (MHT, 156.25mg/kg) and ZTS (0.5g/kg and 1.0g/kg) were respectively perfused into stomach for 8 weeks, and healthy rats were used as control. Then determined the percents of CD~+_3, CD~+_3/CD~+_4 and CD~+_3/CD~+_8 with flow cytometry. Weighed an killed the rats,then weighed the thymus and spleens.The organs coefficient of thymus and spleens and the ratio of CD~+_4/CD~+_8 were calculated. Results: ①The percent of CD~+_3, CD~+_3/CD~+_4 and CD~+_3/CD~+_8 and organs coefficient of thymus and spleens and weight of bodies in diabetic model control group were lower than those of normal group (P0.01). But the ratio of CD~+_4/CD~+_8 was higher than that of normal group (P0.05); ②The all other indexes of ZTS Ⅱ group were higher than those of diabetic model control group (P0.05) except the ratio of CD~+_4/CD~+_8 (P0.05). And except organs coefficient of spleen and the ratio of CD~+_4/CD~+_8 (P0.05), the other indexes in MHT group were significantly increased compared with diabetic model control group (P0.05); ③The index of bodies weight and organs coefficient of thymus in ZTS Ⅱ group were significantly increased (P0.05), but other indexes had no significant difference compared with MHT group (P0.05); ④Except organs coefficient of thymus (P0.05), the other indexes of ZTSⅡ group had no significant difference compared with that of ZTS-Ⅰ group (P0.05). Conclusions: Higher dosage of ZTS has obvious effect of increasing cell immunological function of diabetic rats." @default.
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- W2372242023 date "2006-01-01" @default.
- W2372242023 modified "2023-09-24" @default.
- W2372242023 title "Effects of Zhi Tang Shu on the T lymphocyte subgroups in blood and the immuno-organs coefficients of diabetic rats" @default.
- W2372242023 hasPublicationYear "2006" @default.
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