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- W2372243313 abstract "Objective: To explore the influence of Hei Xiaoyao San on superoxide dismutase(SOD),gluthathione peroxidase(GSH-Px) and malondialdehyde(MDA) of brain tissue and serum in Alzheimer's disease rat model induced by β-amyloid protein(Aβ25-35) fragments so as to discuss the role and mechanisms involved in Hei Xiaoyao San in the prevention and treatment of Alzheimer's disease(AD).Method: The SD rats(n = 94)were randomly divided into sham surgery rats(n = 16) group and model group(n = 94),and all rats of model group received water maze tests for 7 days.These eligible rats were randomly divided 5 groups,model group,positive control group,Hei Xiaoyao San high,medium and low dose groups,14 rats in each group.Aβ25-35fragments was injected into the hippocampus to damage brain neuron to make the rat's AD model.7 days later,all rats of Hei Xiaoyao San group were orally administered Hei Xiaoyao San at low,medium and high doses(4.2,8.50,17.0 g·kg-1·d-1),the positive control group was orally given huperzine A solution 0.02 mg·kg-1·d,model group and sham group received an equal volume double distilled water daily for 28 d.After the last administration,the rats were sacrificed and serum and brain samples collected,and the serum and brain homogenate stration of SOD,MDA,GSH-Px were examined by means of chemistry chromatometry.Result:Compared with the sham group,serum and brain tissue homogenate SOD,GSH-Px of model group decreased significantly,MDA content increased significantly(P 0.05).Compared with the model group,Hei Xiaoyao San obviously increased the activities of SOD and GSH-Px and reduced the content of MDA(P 0.05) in serum and brain tissue.Conclusion: Hei Xiaoyao San can protect rat's AD model from damage,and the mechanisms of which may be related to anti-free radicals." @default.
- W2372243313 created "2016-06-24" @default.
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- W2372243313 date "2013-01-01" @default.
- W2372243313 modified "2023-09-27" @default.
- W2372243313 title "Effects of Hei Xiaoyao San on SOD,GSH-Px and MDA of Brain Tissue and Serum in Alzheimer's Disease Rat Model Induced by Aβ_(25-35) Fragments" @default.
- W2372243313 hasPublicationYear "2013" @default.
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