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- W2372251736 abstract "[Objective] To investigate the alteration of immune function in patients after autologous peripheral blood purified stem cells transplantation.[Methods] Sixteen patients with systemic lupus erythematosus had received autologous peripheral blood purified stem cells transplantation were enrolled in this study.Four-color flow cytometry was used to detect the express of CD+03,CD45RA+CD+4,CD45RA+CD+8 and CD45RO+CD+4 before transplantation and at 3,6,12 months after transplantation.[Results] Frequence of CD+3,CD45RA+CD+4,CD45RA+CD+8 and CD45RO+CD+4 in peripheral blood at 3 months after transplantation were decreased compared with that of before transplantation.At the same time,the subset of CD+3,CD45RA+CD+8 and CD45RO+CD+4 were lower than those of before transplantation(P0.05).At 6 months after transplantation,the CD+3,CD45RA+CD+8 and CD45RO+CD+4 subsets were decreased compared with those of before transplantation(P0.05).CD45RA+CD+4subset was higher than that of before transplantation and 3 months after transplantation.CD45RA+CD+4subset was increased significant at 6 months after transplantation than that of at 3 months(P0.05).Frequence of CD45RO+CD+4in peripheral blood at 12 months after transplantation were also decreased significant than that of before transplantation(P0.05).Frequence of CD45RA+CD+4was higher than that of before transplantation,3 and 6 months after transplantation,only increased significant than that of 3 months after transplantation(P0.05).[Conclusion] Autologous peripheral blood purified stem cells transplantation can reduces the immune function.Measurement of the changes of CD+3,CD45RA+CD+4,CD45RA+CD+8and CD45RO+CD+4cell ratio using flow cytometry may provide insights into the molecular picture of the thymus regeneration function in association with immune reconstruction process in SLE patients after stem cell transplantation.The number of newly generated T cells transported from the thymus can be a putative marker of immune reconstruction after transplantation." @default.
- W2372251736 created "2016-06-24" @default.
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- W2372251736 date "2008-01-01" @default.
- W2372251736 modified "2023-09-22" @default.
- W2372251736 title "Changs of immune function in patients with systemic lupus erythematosus after autologous peripheral blood purified stem cells transplantation" @default.
- W2372251736 hasPublicationYear "2008" @default.
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