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- W2372274830 abstract "OBJECTIVE To investigate the antidepressant and antianxiety effect of proanthocyanidins( OPC) in chronically stressed rats and its underlying mechanism. METHODS One method was selected from 8 different stress methods each day,and the rats were treated with OPC( 25,50 and 100 mg·kg- 1) 1 h before the stress method. The chronically stressed model was established. After 21 d stress experiment,the immobility time in force swimming test,sucrose consumption and the number of marbles buried in the marble burying test were observed respectively each day. OPC( 25,50 and 100 mg·kg- 1) was given 1 h before each test. In addition,Western blotting was used to analyze the expression of brain derived neurotrophic factor( BDNF) and phosphorylated cyclic AMP response element-binding protein( p-CREB) in the hippocampus and frontal cortex. RESULTS Compared with the control group,the chronically stressed group showed obvious depressive-like and anxiety-like behavior,while the immobility time decreased from( 90. 57 ± 4. 27) s in chronically stressed group to( 78. 25 ± 2. 53) s( P 0. 05),( 72. 12 ± 3. 21) s( P 0. 05) and( 60. 77 ± 3. 41) s( P 0. 05) when ig given OPC 25,50 and 100 mg·kg- 1respectively,the ratio of sucrose preference increased from( 42. 80 ± 4. 92) % to( 67. 54 ± 4. 32) %( P 0. 05) and( 72. 21 ± 7. 99) %( P 0. 05) when ig given OPC 50 and 100 mg· kg- 1respectively,the number of buried marbles decreased from 1. 57 ± 0. 21 in chronically stressed group to 0. 63 ± 0. 26( P 0. 05) and 0. 44 ± 0. 18( P 0. 05) when ig given OPC 50 and 100 mg·kg- 1 respectively. The expression of p-CREB in the hippocampus and frontal cortex distinctively increased in OPC group( 25,50 and 100 mg·kg- 1)( P 0.05),so did the expression of BDNF in the hippocampus and frontal cortex in OPC group( 50 and 100 mg·kg- 1)( P 0.05). CONCLUSION OPC can reverse the depressive-like and anxiety-like behavior in chronically stressed rats,which may be related to the cAMP-CREB-BDNF signal transduction cascades." @default.
- W2372274830 created "2016-06-24" @default.
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- W2372274830 date "2014-01-01" @default.
- W2372274830 modified "2023-09-25" @default.
- W2372274830 title "Protective effect of proanthocyanidins on depression and anxiety behavior in chronically stressed rats" @default.
- W2372274830 hasPublicationYear "2014" @default.
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