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- W2372279501 abstract "Wister rats of 7 - old day underwent unilateral common carotid artery ligation and exposure to hypoxic state (8 % oxygen + 92 % nitrogen ) and newborn- rat hypoxic- sichemic encephalopathy(HIE) model was set . The content of malon dialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the brain tissue of rats were measured . The results showed that the content of MDA of the hypoxic- ischemic (HI) group had significantly increased at 6 hour after HI and was the highest at 24 hour and slightly higher than that of the control group(P 0. 05) at 96 hour ; the content of MDA of the HI cerebrolysin- treated group had significantly discreased at 6 hour after HI and then returned to the same level of as that of the control group (P0.05)at 72 hour . The activity of SOD had discreased at 6 hour after HI and was the lowest at 24 hour and then graduly rised again to the level of the control group(P0. 05) at 96 hour;the activity of SOD of HI cerebrolysin-treated group had significantly increased at 6 hour after HI and returned to the same level as that of the control group(P0. 05) at 96 hour . The results suggested that the excessive oxygen free radicals participated the brain damages of neonatal rat after HI and cerebrolysin had the treatment effects on HIE by restraining the produce of the oxygen free radicals and increasing the activity of SOD." @default.
- W2372279501 created "2016-06-24" @default.
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- W2372279501 date "2002-01-01" @default.
- W2372279501 modified "2023-09-25" @default.
- W2372279501 title "Study on the Mechanism of Treatment Effects of Cerebrolysin on Hypoxic - ischemic Encephalopathy of Neonatal Rat" @default.
- W2372279501 hasPublicationYear "2002" @default.
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