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- W2372287777 abstract "Objective To investigate the antibiotic susceptibility of Neisseria gonorrhoeae and to provide a reference for the prevention and treatment of gonorrhea. Methods The susceptibility to 5 antibiotic agents was tested by the disc diffusion method in 108 isolates. β-lactamase was determined by nitrocefin. The fragments including the quinolone resistance-determining region(QRDR) were amplified by polymerase chain reaction(PCR) in gyrA and parC genes, and their relative fragments were directly sequenced. Results Penicillin-resistance rate was 77.8% (84/108),and penicillinase-producing-Neisseria gonorrhoeae (PPNG) 55.6%(60/108); 61.1% of tetracycline-resistant isolates were indentified and high level tetracycline-resistant Neisseria gonorrhoeal (TRNG) accounted for 25.9%. The prevalence of ciprofloxacin-resistance was 83.3%, while none of the strains appeared to be resistant to ceftriaxone and spectinomycin. For fluoroquinolone resistance 22 strains had mutations in gyrA gene at 91 and 95.Mutations at 91 were all Ser→Phe. Mutations in parC gene were at 86,87 and 91. Conclusions Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to treat gonorrhea; Ceftriaxone and spectinomycin can be used as drugs of priority to treat gonorrheau. Mutations of Neisseria gonorrhoeae gyrA and parC genes are concerned with fluoroguinolone resistance." @default.
- W2372287777 created "2016-06-24" @default.
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- W2372287777 date "2005-01-01" @default.
- W2372287777 modified "2023-09-24" @default.
- W2372287777 title "Analysis of resistance of Neisseria gonorrhoeae and mutation of genes for fluoroquinolone resistance" @default.
- W2372287777 hasPublicationYear "2005" @default.
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