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- W2372303465 abstract "Objective To study the levels of interleukin-10(IL-10) and IL-12 in serum of patients with Graves disease(GD) in diffe-rent stage of disease and its clinical significance.Methods The concentrations of serum IL-10 and IL-12 in GD in different stages of disease(preliminary diagnosed,unrelieved,relieved) were measured by enzyme-linked immunosorbent assay(ELISA) and compared with the level of thyroid function:free tetraiodothyronine(FT4),free triiodothyronine(FT3),sensitive thyrotropic-stimulating hormones(sTSH) and thyroid microsomal antibody(TMAb),thyroglobulin antibody(TGAb),thyrotrophin receptor antibody(TRAb) and thyroid-stimulating immunoglobulins(TSI).Results IL-10 and IL-12 levels were significantly higher in the patients preliminary diagnosed than other three groups(Pa0.05),both of them were found to be related with diseases changes.IL-10 level in patients with Hashimoto′s thyroiditis(HT) was negatively correlated with sTSH(r=-0.309 P0.05).IL-10 level in patients with HT was positively correlated with FT3 and FT4(r=0.350,0.334 Pa0.05).Conclusion Both IL-12 and IL-10 are involved in GD and can be signs of disease changing." @default.
- W2372303465 created "2016-06-24" @default.
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- W2372303465 date "2007-01-01" @default.
- W2372303465 modified "2023-09-23" @default.
- W2372303465 title "Changes of Serum Interleukin-10 and Interleukin-12 in Children with Graves Disease and Its Clinical Significance" @default.
- W2372303465 hasPublicationYear "2007" @default.
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