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- W2372305934 abstract "Background:Studies have shown that leptin is closely correlated with liver fibrosis,however,its mechanism in the development of liver cirrhosis is not clear yet.The efficacy of anti-cirrhotic agents used clinically is not satisfactory.Aims: To observe the dynamic expression of leptin and its long form receptor(Ob-Rb)in the developing process of liver cirrhosis in rats,and the interventional effect of tetramethylpyrazine(TMP)on the expression of leptin and Ob-Rb,so as to investigate the mechanism of TMP against liver fibrosis.Methods:60% CCl_4 was injected subcutaneously to induce liver fibrosis model in rats.The animals in prevention and treatment groups were given TMP 10mg/100g per day from the 1st and 31st day of induction,respectively.All the animals in the experimental groups were sacrificed within 12 weeks in batch.Expression of leptin and Ob-Rb mRNA in liver tissue was detected by reverse transeriptase polymerase chain reaction(RT-PCR),and the expression and distribution of leptin and Ob-Rb by immunohistochemistry.Measurements of serum level of hyaluronie acid(HA)and quantitative analysis of collagen in liver tissue were conducted simultaneously. Results:Leptin and Ob-Rb mRNA expressed slightly in the normal liver tissue,and increased gradually after CCl_4 injection,which were positively correlated with the serum level of HA and collagen amount in liver tissue.Up-regulated expression of leptin and Ob-Rb was observed in the portal area,septum,pefivascular and perisinusoidal areas of hepatic lobule,and bile duct in cirrhotic model group,the intensity of expression increased in a time-dependent manner from the 3rd to 12th week.Expression of leptin and Ob-Rb and its mRNA in TMP prevention and treatment groups decreased significantly when compared with those in the cirrhotic model group,so did the serum HA level and collagen amount in liver tissue.Conclusions:Leptin and Ob-Rb are involved in the development of liver cirrhosis.Inhibition of hepatic leptin and Ob-Rb might be one of the mechanisms of TMP against liver fibrosis in CCl_4-induced fibrotic rats." @default.
- W2372305934 created "2016-06-24" @default.
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- W2372305934 date "2007-01-01" @default.
- W2372305934 modified "2023-09-26" @default.
- W2372305934 title "Intervention of Tetramethylpyrazine on Expression of Leptin and its Receptor in Cirrhotic Rats" @default.
- W2372305934 hasPublicationYear "2007" @default.
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