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- W2372324994 abstract "Objective To explore the effect of hypermethylation of multiple site of 5′-CpG islands in the(promoter) regions of O~(6)-methylguanine-DNA methyltransferase(MGMT) genes on colorectal tumorigenesis and(progression).Methods Use a methylation-specific oligonucleotide microarray for quantitative analysis in 20 colorectal carcinomas samples and tissues adjacent to the tumor for hypermethylation detection in MGMT gene promoter.Results Among the 20 samples,MGMT gene hypermethylation was present in 17 cases(85%).The level of hypermethylation in promoter MGMT in colorectal carcinomas was higher than in tissues adjacent(P0.05).Furthermore the levels of 13-15 and 20-23 loci CpG island was much higher than the other three.There was no statistically significant difference of promoter hypermethylation among the samples of different histological grades(P0.05) or samples with different lymph node metastases(P0.05).Conclusions Promoter hypermethylation of MGMT gene is common events in colorectal carcinomas.In addition,MGMT gene has multiple(hypermethylation) patterns.It suggests that epigenetic inactivation of MGMT plays an important role in colorectal tumorigenesis,although hypermethylation of MGMT gene has not been directly related with tumor progression." @default.
- W2372324994 created "2016-06-24" @default.
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- W2372324994 date "2006-01-01" @default.
- W2372324994 modified "2023-09-25" @default.
- W2372324994 title "The quantitative analysis to evaluate methylation status of 5′-CpG island of MGMT gene in colorectal carcinomas" @default.
- W2372324994 hasPublicationYear "2006" @default.
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