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- W2372338645 abstract "Objective To investigate the inhibitive effect of nitric oxide (NO) on the proliferation of periodontal ligament cells (PDLCs) in human.Methods PDLCs were cultured,and 4～8th passage cultured PDLCs were used. The medium was supplemented with SNP as a donor of NO in vitro. The release of NO from SNP was measured by nitric acid deoxidize enzyme in the medium. The quantity of PDLCs proliferation was measured by MTT assay. The ALP activity of PDLCs were measured by continuous observation.Results The release of NO increased along with the enhancement of the SNP concentratio-n. However,the ALP activity decreased with the enhancement of the SNP concentration. The amount of living cells in experimental groups decreased compared with the control groups as shown by MTT test (P0.05). The PDLCs still had the proliferation ability when SNP was removed,and the concentration of SNP had no effect (P0.05).Conclusion Nitric oxide inhibits the proliferation of human PDLCs in vitro." @default.
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- W2372338645 date "2009-01-01" @default.
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- W2372338645 title "Ntric oxide inhibits proliferation of periodontal ligament cells in human" @default.
- W2372338645 hasPublicationYear "2009" @default.
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