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- W2372358324 abstract "OBJECTIVE:To investigate the mechanisms of the mitochondrial DNA mutation in the pathogenesis of gastric carcinoma.METHODS:The mitochondrial mutation from tumor and paired normal DNA was examined by tissue laser capture microdissection and denaturing high performance liquid chromatogragh(DHPLC).RESULTS:The mitochondrial genetic mutation was detected in D-loop region,ND1and ND5genes which belong to electron respiratory chain complexⅠ.The mutation frequencies among them were 50.8%(31/61),39.3%(24/61)and 21.3%(13/61)respectively while the control group of paired normal tissues found no mitochondrial genetic mutation,χ2 were 41.560,29.878and14.550,all P were0.001.According to the sequencing results,there were seventeen mitochondrial mutation locus.Among of them,eleven mutation locus were same sense mutation which did not change amino acid;six mutation locus were mis-sense mutation which can change amino acid.Base substitution was main type accounting for 76.5%(13/17)in mitochondrial mutation.Base transition and base transversion were 23.5%(4/17)and 52.9%(9/17)respectively in the seventeen base substitution.CONCLUTION:Mitochondrial DNA mutation may be one of important reasons for tumorgenesis of gastric carcinoma." @default.
- W2372358324 created "2016-06-24" @default.
- W2372358324 creator A5023984232 @default.
- W2372358324 date "2013-01-01" @default.
- W2372358324 modified "2023-09-24" @default.
- W2372358324 title "Gene mutation of mitochondrial D-loop-(CA)n,ND1 and ND5 in gastric carcinoma" @default.
- W2372358324 hasPublicationYear "2013" @default.
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