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- W2372364013 abstract "Objective Rat models for limb lengthening had been created for future osteogenesis study.Methods Ring fixators were applied to the lower limbs of 12 adult male rats. An osteotomy was made in the diaphysis of tibia. From post operative day 5 onwards, bone fragments were distracted by 0.25?mm twice a day for 12 days. Radiographs were taken weekly. The animals were killed at various stages for histological examination.Results All animals survived the procedures. No adverse effects from the distraction procedure was detected. One animal was excluded due to accidental distal tibial fracture during k wire insertion. Superficial pin tract infectious developed in two animals. The infection settled spontaneously without antibiotics. Postoperative edema in five rats was observed. All resolved without treatment. The bone alignment was good.Conclusion Rat model is good to understanding limb lengthening mechanism." @default.
- W2372364013 created "2016-06-24" @default.
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- W2372364013 date "2003-01-01" @default.
- W2372364013 modified "2023-09-25" @default.
- W2372364013 title "Rat models for limb lengthening" @default.
- W2372364013 hasPublicationYear "2003" @default.
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