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- W2372364132 abstract "Objective To investigate the relationship between spontaneous apoptosis,apoptosis-related genes bcl-2,bax and the radiosensitivity of nasopharyngeal carcinoma(NPC).Methods Terminal oxynucleotidyl transferase mediated dUTP biotin nick end labeling(TUNEL) and immunohistochemical method were used to detect the spontaneous apoptotic index(SAI)and expression of bcl-2 and bax protein respectively in 51 biopsy specimens prior to radiotherapy of NPC.Results The levels of spontaneous apoptosis were observed in all specimens evaluated,the mean SAI was 31.19±33.83.The SAI was not correlated to the expression of bcl-2 protein or bax protein,but was negatively correlated to bcl-2/bax ratio(P0.05).The SAI was obviously correlated with the radiosensitivity of NPC.The SAI in the group without residual tumor was significantly higher than that in the group with residual tumor(P0.05).The bcl-2 protein expression was negatively correlated with the radiosensitivity of NPC(P0.05),while the bax protein expression was not correlated with the radiosensitivity of NPC(P0.05).There was a negative correlation between bcl-2/bax ratio and the radiosensitivity of NPC(P0.05).Conclusion The SAI,bcl-2 protein and the bcl-2/bax ratio are the important parameters reflecting the radiosensitivity and predicting the radiotherapeutic efficacy of NPC,while the bax protein can not be taken as an independent parameter to predict radiosensitivity of NPC." @default.
- W2372364132 created "2016-06-24" @default.
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- W2372364132 date "2008-01-01" @default.
- W2372364132 modified "2023-09-23" @default.
- W2372364132 title "Relationship between spontaneous apoptosis,bcl-2 and bax genes and radiosensitivity of nasopharyngeal carcinoma" @default.
- W2372364132 hasPublicationYear "2008" @default.
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