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- W2372364326 abstract "Objective To investigate the alteration of functional receptors for intermedin in acute myocardial injury induced by isoproterenol(ISO) in rats.Methods Myocardial ischemia injury in rats was induced by subcutaneous injection with ISO(60 mg/kg/day,3days),as experimental group,sham operation group as control.Intermedin(IMD) protein levels in ventricular tissues were examined by Western blot analysis.IMD binding sites in myocardial sarcolemma were determined by radioligand assay.Results Rats treated with ISO,histological sections showed severe myocardial ischemic injury.The plasma LDH activity,plasma MDA content and myocardial MDA content were higher than controls(all P0.01).Heart function decreased greatly and severe heart failure was observed.Western blot analysis revealed that the IDM protein level in ISOinduced rats was 4-folds lower than that of controls.IMD receptors were up-regulated by 118 %(P 0.01),While the affinity to apelin was decreased(Kd increased by 34%,P0.05).Conclusion These results suggest that IDM protein level is down-regulated and the IMD receptor system is up-regulated in ISO-induced myocardial ischemic injury.These changes probably are involved in the development of cardiac injury." @default.
- W2372364326 created "2016-06-24" @default.
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- W2372364326 date "2005-01-01" @default.
- W2372364326 modified "2023-09-25" @default.
- W2372364326 title "Alteration of Intermedin Receptors in Rat with Acute Heart Failure" @default.
- W2372364326 hasPublicationYear "2005" @default.
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