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- W2372378639 abstract "Objective The yeast recombinant hepatitis B vaccine has overcome these limitations and proven safe and effective. Since 1995, a yeast recombinant hepatitis B vaccine produced in National Vaccine and Serum Institute has been put into use in China, while the protective efficacy(PE) of perinatal transmission and anti HBs response are still not clear. The aim of this study is to evaluate the safety and immunogenicity of the yeast recombinant hepatitis B vaccine. Methods 189 infants born to hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers and 373 children aged 6 to 12 years were vaccinated with YRV ( 3 batches from National Vaccine and Serum Institute, 5μg/dose; 1 batch from Amgen, 10μg/dose; 1 batch from Merck, 5μg/dose) by 0, 1, 6 month schedule. Results No serious side reactions were found. The result of one year followed up showed that the PE of vaccines of National Vaccine and Serum Institute was similar to those of Merck and Amgen. The anti HBs positive conversion rates were above 90% after three doses for all 5 groups. It was demonstrated also that the PE of vaccines were not correlated with the geometric mean titres (GMT) of anti HBs. Conclusions This initial results revealed the safety and high PE of Beijing YRV." @default.
- W2372378639 created "2016-06-24" @default.
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- W2372378639 date "1999-01-01" @default.
- W2372378639 modified "2023-09-23" @default.
- W2372378639 title "Safety and immunogenicity of yeast recombinant hepatitis B vaccines(YRV) in clinical trials" @default.
- W2372378639 hasPublicationYear "1999" @default.
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