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- W2372385661 abstract "Objective:To investigate the relationship of expression of matrix metalloproteinase-2(MMP-2)and transforming growth factor-beta1 (TGF-β_1) on ventricular remodeling following myocardial infarction in the rats and the effects of minocycline.Method:Adult male Sprague -Dawley rats underwent the left descending coronary artery ligation,were divided randomly into AMI control group and AMI minocycline treatment group (30 mg·kg-1·d-1) . Rats in these two groups were redivided into 3 subgroups according to the course of treatment: 1 week, 2 week, 4 week subgroups. Eight rats underwent sham operation, were killed at 4 w after operation. The protein expression of Ⅰ, Ⅲ collagen was assessed by the method of immunohistochemical stain. mRNA and protein expression of MMP-2 and TGF-β_1 was examined by reverse transcription- polymerase chain reaction (RT-PCR) and immunohistochemistry.Result:Compared with sham rats, the mRNA expression of MMP-2 and TGF-β_1 significantly increasd in all three subgroups of AMI controls(all P0.05), and the protein expression of MMP-2 and TGF-β_1 were enhanced in all subgroups (all P0.05). Ⅰ/Ⅲcollagen ratio in the noninfarcted myocardium increased subsequently at 2 nd, 4 th week (all P0.05). In comparison with the AMI control group, the mRNA expression and the protein expression of MMP-2 were significantly lower in the 1 w, 2 w and 4 w sub-groups of minocycline group(all P0.05) and so were the expression of TGF-β_1 in the 1 w, 2 w sub-groups(all P0.05). Ⅰ/Ⅲcollagen ratio were also significantly decreased in the 2 w, 4 w sub-groups of the minocycline group (all P0.05).Conclusion:MMP-2 and TGF-β_1 play important roles in postinfarction extracellular matrix remodeling. Minocycline can prevent ventricular remodeling by suppressing the expression of MMP-2, TGF-β_1 and reversing the ratio of Ⅰ/Ⅲ collagen." @default.
- W2372385661 created "2016-06-24" @default.
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- W2372385661 date "2007-01-01" @default.
- W2372385661 modified "2023-09-27" @default.
- W2372385661 title "Effect of minocycline on expression of matrix metalloproteinase-2 and transforming growth factor-beta1 of myocardial extracellular matrix after infarction in the rats" @default.
- W2372385661 hasPublicationYear "2007" @default.
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