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- W2372386546 abstract "Objective To evaluate the therapeutical effect of a clonidine therapeutical transdermal(C-TTS)on mild and moderate primary hypertension its safety.Methods 40 outpatients with mild or moderate primary hypertension were divided into two groups:group 1 C-TTS alone,treated with C-TTS only at the dose of 0.1mg,and group 2 C-TTS plus DHCT,treated with C-TTS plus dihydrochlorothiazide at the dose of 6.25 mg per day.The dose of C-TTS was Adjusting each week according to change of the blood pressure before and after treatment,based on both 24h ambulatory blood pressure monitoring(ABPM)and recording at clinics.Results target level blood pressure(140/90 mmHg)was achieved in 9 patients(45%)in C-TTS alone and 12 C-TTS plus DHCT(60%),respectively,after application of 1 to 3 pieces of C-TTS.The changes of blood pressure levels after various theatment in remaining patients in both groups were significantly lower as compared with their baseline levels(P0.05)and C-TTS plus DHCT induced more reduction both systolic and diastolic pressure than C-TTS alone but not significantly.The 24h recordings of systolic and diastolic pressure,also showed significantly differences,compared with the baseline level,respectively(P0.05).Conclusion ALL the results suggest that C-TTS can efficiently lower blood pressure there for the patients with mild or moderate primary hypertension with good compliance and the hypotensive effect might be better,if combined with small dose of thiazide diuretics." @default.
- W2372386546 created "2016-06-24" @default.
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- W2372386546 date "2007-01-01" @default.
- W2372386546 modified "2023-09-25" @default.
- W2372386546 title "Therapeutical effect evaluation of clonidine therapeutical transdermal on mild and moderate primary hypertension" @default.
- W2372386546 hasPublicationYear "2007" @default.
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