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- W2372390871 abstract "Objective To investigate the role of carbohydrate response element binding protein(ChREBP) in hepatocyte fatty degeneration induced by high glucose concentration.Methods L02 cells were cultured in 18 and 25 mmol/L glucose,using those in 11 mmol/L glucose as control,then determined for triglyceride(TG) content,observed for fatty degeneration by oil red staining and for nuclear translocation of ChREBP by IFA.The expression level of liver pyruvate kinase(LPK) mRNA in the cells was determined by RT-PCR,while that of fatty acid synthase(FAS) protein by Western blot.Results Compared with low glucose concentration,high glucose concentration increased the TG and fatty drop contents in L02 cells,stimulated the nuclear translocation of ChREBP and up-regulated the expressions of LPK mRNA and FAS protein.Conclusion Glucose might induce hepatocyte fatty degeneration by its metabolic product through ChREBP-LPK-FAS pathway." @default.
- W2372390871 created "2016-06-24" @default.
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- W2372390871 date "2011-01-01" @default.
- W2372390871 modified "2023-09-27" @default.
- W2372390871 title "Effect of Carbohydrate Response Element Binding Protein on Glucose and Lipid Metabolism in L02 Cells" @default.
- W2372390871 hasPublicationYear "2011" @default.
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