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- W2372396721 abstract "Objective To determinate the plasma concentrations of cis-or trans-cefprozil and to evaluate the bioequivalence of two domestic cefprozil capsules in Chinese healthy volunteers.Methods Twenty subjects were randomly divided into two groups and the plasma concentrations of cis-and trans-cefprozil were determined by HPLC method after single oral dose of 500 mg cefprozil capsules.The main pharmacokinetic parameters of cis-and trans-cefprozil were calculated and the bioequivalence were evaluated by DAS 2.0.Results The main pharmacokinetic parameters of cis-and trans-cefprozil of test and reference were as follows:tmax were(1.82±0.52) h,(1.65±0.40) h and(1.75±0.30) h,(1.56±0.40) h;Cmax were(7.20±1.24) μg·mL-1,(6.69±1.06) μg·mL-1 and(0.74±0.24) μg·mL-1,(0.68±0.17) μg·mL-1;t1/2 were(1.39±0.38) h,(1.42±0.44) h and(1.12±0.38) h,(1.02±0.25) h;AUC0-12 were(22.07±4.54) μg·mL-1·h,(20.33±3.04) μg·mL-1·h and(1.87±0.38) μg·mL-1·h,(1.73±0.40) μg·mL-1·h;AUC0-∞ were(22.19±4.57) μg·mL-1·h,(20.44±3.04) μg·mL-1·h and (1.96±0.45) μg·mL-1·h,(1.80±0.41) μg·mL-1·h,respectively.The relative bioavailabilities of cefprozil test,calculated by cis-and trans-isomers,were(108.3±11.7)% and(107.7±15.0)%,respectively.Conclusion The reference and test of cefprozil capsules,evaluated by its cis-and trans-isomers,are bioequivalent." @default.
- W2372396721 created "2016-06-24" @default.
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- W2372396721 date "2011-01-01" @default.
- W2372396721 modified "2023-09-23" @default.
- W2372396721 title "Bioequivalence of cefprozil capsules in Chinese healthy volunteers" @default.
- W2372396721 hasPublicationYear "2011" @default.
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