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- W2372405629 abstract "【Objective】 To investigate the expression of Smad4 and Galectin-3 in gastric carcinoma and their correlation.【Methods】 Immunohistochemistry methods of streptavadin-Peroxidase conjugated(S-P) was used to examine Smad4 and Galectin-3 expression in primary gastric cancerous tissues and its corresponding normal tissues.We analyzed the expression of Smad4 and Galectin-3 by HPIAS-2000 Image analysis software.【Results】 Smad4 protein was mainly expressed in the cytoplasm in normal tissues and was decreased in gastric cancerous tissues,especially in the poorly differentiated carcinoma tissues.There was a significance between adenocarcinoma and normal tissue(P 0.01),which was related to the differentiation degree of adenocarcinoma and other clinical factors.It was significantly over-expressed in gastric carcinoma compared with corresponding normal tissue(P 0.001),and it was related to the differentiation of adenocarcinoma and other clinical factors(P 0.05).The degree of enhancement of Galectin-3 immunoreactivity was different corresponding to various histopathological subtypes in gastric cancerous tissue(P 0.001),which was more frequently observed in patients with lymph nodes metastasis(P =0.001).【Conclusions】 The enhanced expression of Galectin-3 and the decreased expression of Smad4 were found in the same gastric cancerous tissue.It is useful to improve the diagnostic accuracy of gastric cancer by detecting Galectin-3 and Smad4 at the same time." @default.
- W2372405629 created "2016-06-24" @default.
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- W2372405629 date "2011-01-01" @default.
- W2372405629 modified "2023-10-01" @default.
- W2372405629 title "Smad4 and Galectin-3 expression in gastric carcinoma and their correlation analysis" @default.
- W2372405629 hasPublicationYear "2011" @default.
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