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- W2372413636 abstract "Objective:To investigate the etiological significance of human papillomavirus (HPV) infection in non-small cell lung cancer (NSCLC) and its association with the expressions of p53 and P-glycoprotein (P-gp). Methods:Polymerase chain reaction (PCR) and SP immunohistochemical (IHC) methods were used to detect the expressions of HPV DNA and its E6 and E7 oncoproteins,p53,and P-gp in 76 cases of NSCLC, respectively. Results:The positive rates of HPV DNA, HPV E6 and E7 oncoproteins in 76 cases of NSCLC were 40.8% (31/76) and 43.4% (33/76),respectively. The coincident rate between PCR and IHC was 78.9% (60/76). The positive rates of p53 and P-gp were 63.2% (48/76) and 59.2% (45/76), respectively. The positive expression of p53 (80.6%, 25/31) was significantly higher in the HPV-positive group than that in HPV-negative group (51.1%,23/45,P0.05). The positive expression of P-gp(68.8%, 33/48) was significantly higher in p53-positive group than that in p53-negative group (42.9%,12/28,P0.05). There was no significant difference in P-gp expression between HPV-positive and HPV-negative group(P0.05). The HPV infection was significantly correlated with highly and moderately differentiated NSCLC and smoking. Conclusion:HPV infection may be one of etiological factors in the occurrence of NSCLC. HPV infection may induce the mutation of p53. Mutation of p53 may increase the multidrug resistance of the lung cancer." @default.
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- W2372413636 date "2006-01-01" @default.
- W2372413636 modified "2023-09-25" @default.
- W2372413636 title "Relationship between human papillomavirus infection and the expressions of p53 and P-glycoprotein in non-small cell lung cancer and its clinical significance" @default.
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