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- W2372438067 abstract "Objective:To study the effects of BMP-2concentration on the inducible differentiation of spinal cord derived NSCs into neural cells,including Neurons and Glial cells.Method:Dissecting the spinal cord of rat embryo pregnanted for14days for primary cultural of NSCs.After4passages,under the presence of bFGF or not,variant concentrations of BMP were added to investigate the proliferation and differentiation of spinal cord derived NSCs.Immunohistochemistry was used to identify the cell type.All the data were analyzed by the statistic.Result:The differentiation of spinal cord derived NSCs into neurons and astrocytes was enhanced at the low concentration of BMP(1~10ng/ml)with bFGF(20ng/ml),and differentiation into oligodendro-cytes was inhibited.High concentration of BMP(100ng/ml)may inhibit the proliferation of NSCs,even make cells death.Conclusion:When incubated with the BMP and the bFGF,Spinal cord derived NSCs can differentiate into neural cells in vitro.These neural cells have high homology with spinal cord.So it is the hope for repairing spinal injury." @default.
- W2372438067 created "2016-06-24" @default.
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- W2372438067 date "2004-01-01" @default.
- W2372438067 modified "2023-09-27" @default.
- W2372438067 title "Study on the effects of BMP-2induced the differentiation of spinal cord derived NSCs" @default.
- W2372438067 hasPublicationYear "2004" @default.
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