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- W2372439563 abstract "Objective To assess application value of CT perfusion imaging(CTPI)combined with methazolamide stress test in observation of cerebrovascular reserve capacity changes in spontaneous hypertensive rats(SHR).Methods Totally 20rats including 10in SHR group and 10in normal control group underwent cerebral CTPI before and after intragastric administration of methazolamide.Cerebral blood volume(CBV),cerebral blood flow(CBF),mean transit time(MTT)and time to peak(TTP)values of ROI were measured before and after methazolamide stress test.The arteriolar wall thickness and microcirculation capillary network were observed under light microscope after HE staining of paraffin section,and cerebral infarction in brain was analyzed using TTC staining.Results CTPI showed that there were statistical differences of four perfusion parameters between resting state and load state in two groups(all P0.05).CBV and CBF increased,while MTT and TTP shortened in the load state.TTP were statistical different between two groups in the resting state(P 0.05).MTT and TTP had statistical differences between two groups in the load state(P0.05),and MTT changed more significantly.The arteriolar wall thickness had no statistical difference between the two groups(P0.05),but there were statistical differences in microcirculation capillary network number(P0.05),and the number of microcirculation capillary network of SHR relatively increased.The brain tissue of SHR had no cerebral infarction.Conclusion CTPI combined with methazolamide stress test can reflect the changes of cerebrovascular reserve of spontaneous hypertensive rats." @default.
- W2372439563 created "2016-06-24" @default.
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- W2372439563 date "2014-01-01" @default.
- W2372439563 modified "2023-09-27" @default.
- W2372439563 title "CT perfusion imaging after administration of methazolamide for observation on cerebrovascular capacity of spontaneous hypertensive rats" @default.
- W2372439563 hasPublicationYear "2014" @default.
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