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- W2372461831 abstract "Aim To evaluate the protective effects of XCG-7,an anticomplementary polyphenol from the seed of Toona sinensis(Meliaceae) on activation and injury of endothelial cells induced by complement.Methods Normal human serum was activated by cobra venom factor,a specific activator of alternative pathway from cobra venom.The endothelial cells were exposed to the mixture of XCG-7 and activated serum.After incubation,expression of P-selectin,E-selectin and IL-8,and leakage of lactate dehydrogenase and activity of caspase-3/7 were determined,respectively.Results XCG-7 inhibited the expression of P-selectin,E-selectin and IL-8 induced by activated complement,and decreased lactate dehydrogenase leakage and caspase-3/7 activity.Conclusion The anticomplementary polyphenol XCG-7 from the seed of Toona sinensis can protect endothelial cell from complement-induced activation and injury." @default.
- W2372461831 created "2016-06-24" @default.
- W2372461831 creator A5024300595 @default.
- W2372461831 date "2011-01-01" @default.
- W2372461831 modified "2023-09-22" @default.
- W2372461831 title "Protective effects of a polyphenol from the seed of Toona sinensis on activation and injury of endothelial cell induced by complement" @default.
- W2372461831 hasPublicationYear "2011" @default.
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