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- W2372463023 abstract "OBJECTIVE To detect the ESBL-producing strains from lower respiratory tract samples and identify the risk factor of ESBL-producing strains infection. METHODS Klebsiella pneumoniae and Escherichia coli were collected from lower respiratory tract samples. Microdilution method was used for antimicrobial susceptibility test. Double-disk synergy test was used to detect ESBL-producing strain, and the pI of β-lactamase was identified by isoelectric focusing. Risk factors of ESBL-producing strain infection were analysed with Logistic regression. RESULTS From Mar. 1998 to Oct. 1998, 126 strains of K.pneumoniae and 29 E.coli were isolated from lower respiratory tract samples. All the 39 ESBL-producing strains were strains of K.pneumoniae. Thirty three ESBL-producing strains produced one kind of β-lactamase, six strains produced two different β-lactamases. The β-lactamase of pI 7.6 was the major enzyme followed by β-lactamase of pI 8.2. The resistant rate of ESBL-producing strains to 11 antibacterial agents was significantly higher than that of non ESBL-producing strains. Relative risk of previous use of the third generation of cephalosporins and admission to ICU were 3.26 and 6.09, respectively. CONCLUSIONS Isolation rate of ESBL-producing K.pneumoniae from lower respitatory tract was high in the hospital and the major ESBL was SHV type. ESBL-producing strain acquisition depends on previous use of the third generation of cephalosporins and admission to ICU." @default.
- W2372463023 created "2016-06-24" @default.
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- W2372463023 date "2002-01-01" @default.
- W2372463023 modified "2023-09-25" @default.
- W2372463023 title "Surveillance of Lower Respiratory Tract Infection of ESBL-producing Strains and Analysis of Risk Factors for Acquisition" @default.
- W2372463023 hasPublicationYear "2002" @default.
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