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- W2372472785 abstract "Objective:To observe the effect of chemotherapeutic drugs on nude mice bearing human bile duct carcinoma.Methods:Human moderately differentiated bile duct carcinoma nude mouse model was used. 45 nude mice bearing human bile duct carcinoma were divided into 7 treated groups and one control group. Each treated group had 5 mice and the control group had 10 mice. On the day of classification,mouse weights were taken and drug was injected intravenously once via vena caudalis. The doses of drugs administrated were as follows:MMC 4 mg/kg,ADM 10 mg/kg,VCR 0.20 mg/kg,TAXOL 20 mg/kg,DDP 10 mg/kg,CTX 120 mg/kg,5-Fu 120 mg/kg. 0.2 ml of physiological saline solution was used for the control mouse. During the experiment,tumor sizes were measured twice a week and relative tumor proliferation rates were calculated. At the end of the experiment,mouse weights were measured again,changes of body weights were detected.Results:Relative tumor proliferation rates of MMC,ADM,VCR,TAXOL,DDP,CTX groups were 1%,23%,39%,47%,51% and 86%,respectively and increases of mouse body weights were 21%,0%,11%,1%,14% and 8%. 80% mice in 5-Fu group died during the experiment. It showed 5-Fu had toxic effect.Conclusion:MMC,ADM,VCR,TAXOL and DDP exhibit therapeutic effect on nude mice bearing human moderately differentiated bile duct carcinoma,however,CTX doesn't show such effect." @default.
- W2372472785 created "2016-06-24" @default.
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- W2372472785 date "2004-01-01" @default.
- W2372472785 modified "2023-09-25" @default.
- W2372472785 title "Effect of chemotherapeutic drugs on nude mice bearing human bile duct carcinoma" @default.
- W2372472785 hasPublicationYear "2004" @default.
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