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- W2372474815 abstract "Objective To study the clinicopathological features,immunophenotype and differential diagnoses of renal oncocytoma.Methods Clinical manifestations,radiological,histological characteristics and immunophenotypes were analyzed in 10 cases of renal oncocytoma.Results 4 male and 6 female patients,with ages ranging from 44 to 78 years(mean 57.8 years),and six cases located on the right side and four on the left side.Multifocal disease was noted in 1 case.Grossly,the tumors were all well circumscribed with brown to tan cut surface and sized 1 to 10 cm in diameter.Central fibrous scar was noted in three cases.Histologically,the tumor cells were mainly arranged in closely packed nests,acini or tubules and occasionally microcystic pattern in loosely edematous and fibrous stroma.Tumor cells had moderate to abundant granular eosinophilic cytoplasm with a small,round and uniform nucleus containing finely and evenly dispersed chromatin,but focal nuclear atypia was also seen.Mitotic figure was absent or rare.Immunohistochemically,all cases were diffusely positive for CK18 and E-cadherin,and showed variable immunoreactivity for CD117,CD10 and CK7,of which 9 cases were positive for EMA.But all cases were negative for vimentin,34βE12,HMB45 and S-100.The proliferating index(Ki-67) was very low in all cases,with less than 1% of the nuclei labeled Conclusions Renal oncocytoma is a rare benign tumor of the kidney with excellent outcomes.That the tumor cells arrange in nests or acini architectural pattern with loosely hypocellular and edematous stroma is the most important histological feature." @default.
- W2372474815 created "2016-06-24" @default.
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- W2372474815 date "2011-01-01" @default.
- W2372474815 modified "2023-09-26" @default.
- W2372474815 title "Renal oncocytoma:a clinicopathologic study of 10 cases" @default.
- W2372474815 hasPublicationYear "2011" @default.
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