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- W2372474880 abstract "To investigate the expression and clonality of TCR V beta subfamily genes in the T cells in polycythemia vera.The 24 genes of the TCR V beta subfamily were amplified with peripheral blood mononuclear cells from 3 cases of polycythemia vera(PV) by RT-PCR, then the PCR products were further analyzed by genescan technique to evaluating the clonality of the detectable TCR V beta T cells.Only 4-14 of the 24 V beta subfamily T cells were found in the 3 PV cases, the commonly expressed V beta subfamily genes were V beta 2, V beta 3, V beta 16, V beta 21 and V beta 23. Two clonal T cells of V beta 3 and V beta 23 were identified in 2 cases.The skew distribution and clonal expansion of TCR V beta subfamily T cells in patients with polycythemia vera might be a feature of the immune response for malignant cells." @default.
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- W2372474880 date "1999-11-01" @default.
- W2372474880 modified "2023-09-23" @default.
- W2372474880 title "[The feature of T cell clonality with polycythemia vera]." @default.
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