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- W237248498 abstract "Diet is considered to be a potentiai1y modifiabie exposure which might give opportunities to reduce breast cancer incidence (l ). It is, however, not known which specific factors are the most important causes of breast cancer in the Netherlands. Results of correlation studies suggest that the relativeiy high Dutch breast cancer incidence and mortality (2) might be expiained by the high per capita fat intake (3) and the presumabiy low selenium intake (4). These associations are al so demonstrated in animal studies (5). Up to now, case-control sttudies on diet and breast cancer have mainly focused on animal products (6) or dietary fat (6-8) and consumption of alcoholic beverages (9-ll). Also, in two cohort studies (12,13) positive associations with animal products and fat-containing foods were found, while several Japanese foodstuffs were negatively associated. These dietary components are thought to promote neoplastic disease. 0n the other hand, selenium is suggested to be a protective agent against cancer in generai (14). Case-control studies showed contradictory results in blood selenium levels between breast cancer cases and controls (15,16). Two recent prospective studies have reported an inverse relation between a low prediagnostrc selenium level and subsequent (all sites) cancer risk (14,17). 1n general, however, these studies were small and site specific analyses could not be studied with much statistical power (14,l8). Also, a protective effect has been found of increased blood levels of vitamin t, possibly of s-carotene, but not of serum retinol (l9)." @default.
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- W237248498 date "1985-01-01" @default.
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- W237248498 title "Dietary selenium, selenium status, fat consumption and body composition: a case-control study on the etiology of pre- and postmenopausal breast cancer" @default.
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